HIV

Improving Advanced HIV Disease Ourcomes with IMPAACT4HIV

The Improved Access to AHD Care and Treatment for HIV (IMPAACT4HIV) project is a Unitaid-funded project dedicated to enhancing access to optimal diagnosis, prevention, treatment, and innovative delivery mechanisms for Advanced HIV Disease (AHD).

Despite significant investments in HIV, mortality rates remain unacceptably high, with one-quarter of HIV-related deaths occurring in sub-Saharan Africa. In 2022, 630,000 HIV-related deaths were reported globally, half of which were due to advanced HIV disease. This condition disproportionately affects children under five, who are at high risk of severe illness and death.

Advancing Science, Saving Lives: Our Clinical Trials Legacy

The Aurum Institute has been at the forefront of global health research for over two decades, conducting over 224 clinical trials and enrolling more than 67,000 participants across six state-of-the-art Clinical Research Sites in South Africa and Mozambique.

Our portfolio spans HIV prevention and treatment, tuberculosis innovations, COVID-19 vaccine rollouts, and reproductive health, reflecting our commitment to responsive and transformative science.

The trials featured below illustrate the breadth and depth of our research, ranging from early-phase safety studies to large-scale, multi-country vaccine trials. Whether investigating long-acting PrEP, host-directed TB therapies, or pandemic preparedness, each trial is a step forward in improving health equity and saving lives across communities.